The best option is a taxi (22-25 EUR). Fixed price.
By Bus: airport bus to the Prado de San Sebastián. There take bus 34 and get off at the last stop on the Avenida de Reina Mercedes.
By car: A4 towards Cadiz. Output Avenida de la Palmera. Turn left down the street Ifni. Take the street Amazonia up to the Uruguay street.